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Genes tied to aggressive melanoma spread unearthed
Two research teams studying melanoma using gene expression profiling identify sets of active genes linked to invasive tumors. One team cites up to 200 genes, MIT researchers narrow to 32 and show RhoC increases invasiveness in mice while blocking it reduces aggression. Findings published in Nature suggest genetic tests to flag at risk patients and new therapy targets.
MENTIONED IN THIS ARTICLE
Jeffrey Trent
National Human Genome Research Institute
Bethesda
Trent
Massachusetts Institute of Technology
MIT
Richard Hynes
Nature
Hynes