Hopkins doctors use thalidomide to treat GVH after transplant
Johns Hopkins Oncology Center doctors have begun using thalidomide to combat graft-vs-host disease in bone marrow transplant patients. Once infamous for birth deformities, the drug is praised as a potent tool, with about 90 patients treated, facing hair loss, muscle stiffness, and severe rashes as GVH manifests.
MENTIONED IN THIS ARTICLE
Baltimore
Johns Hopkins Oncology Center
Gary Gordon
Hopkins
Thalidomide resurrects hope in immune disorder treatment
Dr Gordon left Hopkins to join a pharma firm and, with Dr Georgia Vogelsang, began testing thalidomide for GVH and leprosy after late 1960s research. In humans 60 percent of severe GVH patients improved, with many avoiding further therapy after stopping treatment. Immunologist Dr Gilla Kaplan notes the drug lowers tumor necrosis factor, dampening harmful immune cascades.
MENTIONED IN THIS ARTICLE
Gordon
Hopkins
Georgia Vogelsang
Vogelsang
Gilla Kaplan
Rockefeller University
Gene flaws tied to both inherited and noninherited cancers
New evidence shows BRCA1 gene flaws appear in noninherited ovarian tumors and reduced BRCA1 activity is linked to noninherited breast cancer. Studies from Michigan, Pennsylvania, NIH, Vanderbilt, and UK-Canada teams suggest BRCA1 defects or diminished control may drive about 10 percent of noninherited ovarian cancers and contribute to breast tumors, with broader implications for cancer genetics.
MENTIONED IN THIS ARTICLE
New York
Nature Genetics
Vanderbilt University School of Medicine
Nashville
Tenn
Vanderbilt
Jeffrey Holt
Barbara Weber
University of Pennsylvania School of Medicine
Philadelphia
Smoking moms linked to oral clefts in babies
Johns Hopkins University studied 467 Maryland births from 1984 to 1992 finding mothers who smoke raise risk of oral clefts in children with the defect strongest when the child carries a specific gene. The study notes 183 clefts in the group and cites 6 times higher risk for gene carriers with smoking mothers.
MENTIONED IN THIS ARTICLE
Baltimore
Johns Hopkins University
Maryland
Terri Beaty
Sharon Rippey
Johns Hopkins School of Hygiene and Public Health
American Journal of Epidemiology
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Souwale
Scottsdale Securities, Inc
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Executive Blvd
Rocktile
Quick & Reilly
Waterhouse
Heyes
First General Mortgage Company
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Montgomery, Howard Counties
Frederick County
Baltimore Area
Bob Evans
Frederick, MD
Winchester
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