Most antidepressants show limited effect on general depression
A study finds most antidepressants have little impact on mild to moderate depression while showing greater effect in severe cases. Researchers analyzed multiple trials and conclude benefits are modest for the typical patient, with larger gains in those with more severe symptoms.
Research links antidepressants to limited benefit in mood
A Canadian expert urges caution after a study by Irving Kirsch showing four new generation antidepressants offer little to no advantage over placebo for moderate low mood and only minor improvement for severe cases. The February 26 PLoS Medicine report suggests many can improve without chemical treatment.
MENTIONED IN THIS ARTICLE
Edmonton
Irving Kirsch
Plos
Public Library of Science
Arun Ravindran
University of Toronto
Centre For Addiction and Mental Health
Antidepressants Debate Highlights Individual Patient Needs
Doctors caution that low mood is not a simple illness and treatment must be tailored. Studies show antidepressants offer little advantage over placebo except for the most severely depressed patients, with risks of GI issues, sexual side effects, weight changes, and drowsiness.
MENTIONED IN THIS ARTICLE
Ravindran
Kirsch
Canada
IMS Health Canada
University of Hull
U.K
Prozac
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