Baltimore. Feb. 15.Destructive Fire at the Baltimore Museum.— We announc e with regret the occurrence of a destructive fire on Thursday morning, at the spacious and elegant brick structure on the north west corner of Baltimore and Calvert streets, owned by Mr John Clark, and occupied princi-nully by the Baltimore* Museum and Gallery of, Fine Ai t*. One of the chiinmes of the house I •wok fire between nine and ten o’cloc k on Wed-! nesday night, and every thing was believed to be safe between elevpn and twelve: but at one o’clock in the morning the Museum was discover- ] i*lt;J to be on fire in the fifth story or the roof, aud j dthough the firemen were on the spot with their jlt;oal promptitude, the flames hud Rained such ! ascendancy that it appeared for some time doubt- f ful whether the whole hou»e would not be destroy -•d. A strong north west wind also prevailed, whi» h tended to increase the power of the fire while it interfered with the advantageous action •»f the engines The energetic and effective ex--rtions of the firemen, however, at length prevailed, and the lower stories of the house were 1 reS' ui-d from deduction.The greatest loss sustained was in the total de-struction of in* e\».*iiMve and valuable Anatomical Cabinet, con i I g « f preparations in was, valued at $tl),UUU. It wu.'piaied in the fifth Htorv, and was coovumed befoic any attempt ci-uld be made to rescue it. In the fourth story *nm;v curiosities were either totally desttoyed by I the fire, or greatly injured by a hasty removal — I The third story was anpmpnated to the Gallery of paintings. These, we are glad to learn, were 1 nearly all saved, though mnne of them are injured : or defaced.From the second story of the building (the j, first floor of the Museum) the articles were re- j ■ moved to a place of safety, but in a more or let* 1 damaged condition. The first story or basement was occupied as follows: 00 Baltimore street, by Messrs. Leonard, Jones Co. hatters; Mr. Wm. Birch, paper hanger, insured; Mr. J. B. Preston, fancy store, insured; Mr. Joho Clark, Lottery office; aud on Calvert street, by the Phoenix Line Stage Office, and by Mrs. Popple-ton, confectioner. Tnuse stores were completely deluged with water, and though much of their contents was removed, considerable damage was sustained by the occupants.The injury done to the house was the complete destruction of the roof, and the floors of the fourth and fifth a'oriet and material, damage by fire and water to most of the other parts.—■ The building, we learn, waa fully covered,and it it said that insurance was also effected on tbe contents of the Museum. We understand the house will be apt dily repaired, and we are not without tn« hope that so many of the curioaities of the Museum have been preserved that this interesting establishment may be re-opeucd without delay.—American.