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Lethbridge Herald Newspaper Archives

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Lethbridge Herald, The (Newspaper) - November 2, 1972, Lethbridge, Alberta JO THI LffHMIDGE HERAID Tliundoy, 3, 1972------ TIGHT FIT even for a giant ciliper a huge tire gels a final (Citing at a planl in Ak- ron, Ohio. The eight-tool, all- radial is designcil for earthraovers. Medication of patients Doctors' say on drug brand stressed IH GLENNI5 Z1LM OTTAWA (CP) Only floe- tors s li o u 1 tl deride which brand of medication their pa- tients arc Riven and il is ''pre- mature" to allow others on the health team to substitiile other brands automatically, says Dr. Ian Henderson of I lie University of Ottawa medical school. The associate professor of both pharmacology -ind sur- gery was commenting in an interview about the problem of "equivalence." .which he termed "an exceedingly com- plex issue.'1 "Mandatory legislation, where druggists are required lo substitute the cheapest brand, is premature and such laws can't be wisely adminis- he said. However, six from Quebec some form of substitution leg- islation on their books, allow- ing, but not necessarily re- quiring, substitution. And doctors appear lo he growing increasingly con- cerned about this, especially in view of recent questions aboul whether chemically similar brands Fire really i equivalent whe nabsorbed in i the body. Dr. Henderson is char-man ot Hie subcommilloe on phar- macy for the Canadian Medi- cal Association but said he was speaking as ;MI individ- ual. He also has helped set up n drug information service for doctors at the Ottawa General Hospital awl works with the federal gove 'nmenl drug test- ing laboratories DOUBTS AKISE Recent studies on bioavaila- refers lo how a drug is absorbed in the body raised some doubts aboul substitution legislation, he said. This is a relatively new concern, arising alter re- ports about wide price varia- tions among seemingly simi- la drug brands had led politi- cians to bring in such legisla- tion. Dr. Henderson said that in determining equivalence or "equalness" of any drug, there are three main factors: chemical equivalence, biologi- cal equivalence frequently referred lo as bioavailabilily and therapeutic equivalence. Chemical equivalence can be fairly readily determined by laboratory analysis, he said. For example, il's relatively easy to determine whether tuo tablets contain equal amounls of drug, what percentage is fill- er material and how fast the tablet ingredients dissolve. Unavailability is more com- plex. Here, researchers must determine how much of the drag gels into the body in a useful form, usually by rinding out how much is circulating in the blood, how long it remains in the body or how it is ex- creted. SEEK COMPARISON Researchers now are deter- mining how to measure these things and. more important, how to compare them. But Dr. Henderson said there still is considerable con- troversy over what testing should be done and whether it is all useful. Another problem is that this research is time- consuming and costly. To doctors, therapeutic equi- valence or how effective the drug is against disease in an individual is the most im- portant thing. "And what we know al pres- ent about therapeutic cquival- I ence is just not good Dr. Henderson said. "This hasn't been studied at all yet." Numerous [actors govern therapeutic equivalence, mak- ing il difficult to delermine how effective drug is. Some patients may be aller- gic to the filler or to the drug itself, or they may absorb more of (he active ingredient or less. No Iwo people have identical reactions. The disease also is impor- tant how extensive it is or what area is affected. There may be interactions with other drugs or even with certain foods the patient past. CITES DANGERS Dr. Henderson also said re- sead'chers are finding varia- tions that can exist in chemi- cally identical but physically distinct forms of the drug. These can only be found by special techniques. These individual therapeutic variations have led lo situa- tions, There when on brand has been substituted for an- other, patients have nearly died, Dr. Henderson said. Serious consequences have been record- ed with heart drugs such as digoxin, oral diabetics such as tolbulamidc and hormones such as prednisone. These adverse reactions are no reflection on manufacturer or prices. It's merely that whe a patient has been making gooc progress on one brand and an other brand is substituted, the patient may gel sick. Therefore many doctor want lo rely on (heir past ex periences with a drug ani don't want substitution withon their knowledge. They want t use a brand which has worke in their experience both with the individual and the drug. Survive fall HARTFORD, Conn. (AP) Two women and a two-year-olc boy IB an auto survived a five- storey plunge from a parking garage without serious injury Police said the car jumped curb and smashed through a concrete retainer wall in the high-rise parking garage of the Hartford Hospital and plunged five storeys on to two unoccu pied cars below. from Simpsons-Sears These are just a few of the outstanding new lighting ideas from our current value-packed Simpsons-Sears catalogue. They are now on display along with many others in our lighting department. Come see and be dazzled! at Simpsons-Sears you get the finest guarantee islkfacllon or money refunded and Iroo delivery fttir scrvicft bnqma wiih Ihn snlfi prolocts you nvcry Inch of iho way (Duality Costs No More al Simpsons-Scars STORE HOURS: Open Dally 9 a.m. lo p.m. Thursday and Friday 9 a.m. la 9 p.m. Centre Village. Telephone 328-9231 A NEW TWIST A bull's eye, maybe, but II be o Picasso's version of a bull. Artisl Paolo Brambilla of Bologna, llaly, aiming to be different, uses a rifle in- slead of a brush for his new art form a design made of bullet holes. Martha tells story of her squabble By CLARE CRAWFORD committee after Mitchell's res- Washinglon Star News ignalion. The source said that the injection had not made Mrs. WASHINGTON-Martha Mit- chell has broken her two-month silence to tell details of her squabble last June over her husband's political role. She said she has written a letter to a magazine to give icr version of what happened in Newport Beach, Calif., when she was given an injection in he buttocks "against my will." Mrs. Mitchell said she was upsel by a Parade Magazine Mitchell unconscious and that "her version of what happened in the Newport Hotel room was accurate that variations in the story were simply a mat- ter of degree." -Mrs. Milchell said she does not know what caused King, who was then acting as her bodyguard, lo pull the telephone out of the wall. She said she. was in bed in her hotel room in item which reported that Sieve i King, Ihe new security director nhnn" :or the committee to re-elect he president, "was not in- volved" and did not give her he injection. HELD HER DOWN. Mrs. Mitchell said doctor her Ihe injection, not Cing. However, she said, King leld her down while the injec- She said he hurl her hand and he wound required six stitches Shortly thereafter, Mrs. Mit- :hell showed a reporter band- ages on her ring and middJe ingers and bruises on her arms. She also spoke to another re- of burning her hand. phone to UPI reporter Helen Thomas about her demand that her husband former Atty. Gen. John Mitchell, resign as chair- man of the re-election com- mittee. DIRTY BUSINESS She said she had just told Miss Thomas that politics was a dirty business when King pulled the telephone out of the ion was administered. "He j wall hrew me down and kicked me Miss Thomas, at (hat time, vith his rubber soled shoes." reported she had asked Mrs. Mitchell a question about the bugging of the Democratic national committee the week- end before by men allegedly connected with the re-election committee. Mrs. Mitchell answered that she had given her husband an .here have been subsequent un- "ultimatum" lo get out of poll- Jrinted reports that she was -----IJ liven an injection by a doctor or pain from the burned hand. Mrs. Mitchell made her com- lents in a telephone call. She didn't seem upset. Her mood more one of disgust that 'people keep saying these hings about me that aren't rue." DENY RUMORS A source close to her hus- and, former attorney general ohn Mitchell vehemently de ied rumors and speculation hat Mrs. Mitchell had had a ervous breakdown. Republi- ans at the highest level have Jeen whispering and inferring hat Mrs. Mitchell is and has icn "III." 8 "Absolutely said ic source close to Mitchell, 'he source pointed oul that Cing had been promoted to sec- rity chief for the re-election "Before she could go Miss Thomas said, "I heard her pro- test: 'You just get away.1 "At that point our connection was broken and the attempt to get her back met with word from the operator 'Mrs. Mit- chell is indisposed and cannot talk.' Mrs. Mitchell said again she did, not know what caused King to rip the telephone out She said he also pulled the telephone out of the room of her daughter, Marty, H. Mrs. Mitchell said she was kept a prisoner in the hotel for 24 hours without food. She said her secretary Jablonsky, took Marty out to eat, but did not assist her in any way. She said she was unable to contact her husband and she was not allowed to call for room service or a maid. Boyle's column By HAL BOYLE NEW YORK (AP) Re- marks a secretary gets tired of hearing: "Honey, if you want to get j to the in this outfit, you j have to learn the right lap to sit on." "Good heavens. I knew you probably couldn't spell. But can't you take dictation ei- "I don't just want a girl Friday. I want a girl Monday, Tuesday, Wednesday, Thurs- day. Friday and sometimes weekends." "I know it doesn't look right for an executive to borrow money from his secretary, Mua Grant. Bui can you let me have until day after "If my wife calls. I'm in conference. If it's any other woman, put her on the line." "Miss Grant, are you sure you spell sour apples the same way you spell sauer- FOLLOW EXAMPLE "The trouble with secre- taries ts that they keep trying lo act like their bosses. As soon as I started drinking a three-martini lunch, my sec- retary Jumped from a one- to a two-martlnl lunch." Grant, I think you mutt have [alien In love with your boss. No girl could work for a bee! like him unless she loved him." "Miss Grant, I see you hsva spelled the world sterilize with an "uh" in It again. Really. Miss Grant, "1 don't see why you have (rouble making both ends meet on the saiary I pay you. Miss Grant. Don't some of these salesmen you let hito the office lo see me slip you n S5 or S10 on the side, now and "d'ond a f I e r n oon, MIBS Grant. Oh; it is still morning? You're so late today that I thought maybe you'd stop off for lunch before you come in." "Please. Miss Grant, pa. liont as I am, I can't pul up with spelling delinquent with a 'kw' in it." "I'm in a big rush to get away for Ihe weekend, Miss Grant. Will you stay late to- night and answer then let- ters? You know what I want rt to say as well as I do. Don't forget to put in n lab for J2 or so for dinner." you Ret fired, Phoclw, ot ordering all (hone theatre tickets and anniver- sary roses for your boss's wifo? Don't you sometimes wish they worn for you in- ;