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Lethbridge Herald Newspaper Archives

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Lethbridge Herald, The (Newspaper) - June 14, 1973, Lethbridge, Alberta THE IETHBRIDCE HERALD Th 14> >973 Not very encouraging admits Lalonde Gonorrhea vaccine fails in test case By JEFF ARRUTHERS OTTAWA With the in- cidence of venereal disease in Canada and throughout the world continuing to escalate, it is bad news indeed that has come out of last year's Inuvik, N.W.T. trial of a Canadian-de- veloped gonorrhea vaccine. In a phrase, the vaccine doesn't work. In fact, the supposedly non- active placebo used in the trial ould almost seem to be better than the vaccine. Thirty percent of the volun- teers given the vaccine devel- oped gonorrhea anyway. Twenty-six percent of the vol- unteers given the placebo sub- sequently developed gonorrhea. Health Minister Marc Lalonde said Tuesday outside the Com- mons that "up until now. the vaccine does not look very en- couraging." Dr. A. B. Morrison, head of the health protection branch. said that the vaccine has no effect' in preventing gonorrhea. But he added that "the possi- bility of a vcacine is still suf- ficiently attractive theoretically for us to continue trying." So it's back to the drawing boards and the laboratory, for much more experimentation on animals. And at this time, the prospects of any further human trials seem dim indeed. The vaccine, a crude prepara- tion containing killed gonoc- cocal bacteria, was developed by federal health department scientist Dr. Louis Greenberg in Ottawa several years ago. Dr Greenberg is now with the Pan American Health Organization in Washington, B.C. The Inuvik trial, started in January 1972, was the first hu- man trial of the effectiveness of the vaccine. Slightly more than 60 volunteers, most of them members of the native popu- lation, were involved. Inuvik was selected in part because it was isolated and in part be- cause there was a high in- cidence of gonorrhea there. A second, much larger trial planned for Uganda, in- volving up to University Of Makerere students and sched- uled to start last fall. The Uganda trial never started, re- portedly as a result of the un- stable political situation in Uganda at the time. Now, health department sci- entists say the Uganda trial would likely have been stopped, for scientific reasons, even if it had started on time. The scien- tists say the Inuvik results were that disappointing. Dr. Greenberg had com- mented that a vaccine with a stronger kick to it would have shown better results in any post-Inuvik human trial. But Ottawa officials yester- day said the Inuvik data pro- vides "no reason to believe a stronger more concentrated vaccine would have given a dif- ferent result in the Uganda trial." The "back to the drawing boards' effort has already be- gun. The government scientists are now trying to develop an animal model, for studying go- norrhea and for testing any fu- ture vaccines. Only after ade- quate animal testing is com- pleted will the department con- sider doing any more human testing of a gonorrhea vaccine. The department has also recently started studying sam- ples of blood from Ottaua-area individuals infected with go- norrhea. The scientists are in- terested in studying what tyocs and what levels of antibodies are produced in humans es a result of exposure to gonorrhea. The idea is to determine what types of levels of such anti- bodies a vaccine would need to produce in humans to be effec- tive. In the Inuvik trial, 56 percent of those vaccinated showed signs of increased levels of neu- tralizing antibody thought to be related to immun- ity to gonorrhea. By com- parison, 27 percent of those given placebo developed similar increased antibody levels. At the same time, at least four of the 10 vaccinated volun- teers who subsequently devel- oped gonorrhea also had devel- oped increased anbibody levels in their blood. By numbers, 10 cf the 33 vac- cinated volunteers in the Inuvik trial developed gonorrhea after the vaccination. And seven of the 29 volunteers given a pla- cebo subsequently developed go- norrhea. Pondering a question Foot on desk, William D. Ruckelshaus, temporary director of the FBI, deep in thought over a reporter's question during a news conference in Washington._________ Snowmobile expedition turns back PINE CITY, Minn. (AP) The Minnesota-to-Moscow snow- mobile expedition has turned back, after four hectic days on the Arctic ice cap. Bill Cooper of Willow River, Minn., head of the five-man ex- pedition, radioed here Tuesday that the team was turning back to Ellesmere Island off the coast of Greenland. He said the snowmobiles would be stored in the island until the expedition is resumed in the fall. Cooper said a plane was expected to pick up the party late in the week. PICNIC STYLE PORK SHOULDER GOVERNMENT INSPECTED 9 e Don't Miss These Specials FLETCHERS RINDLESS SLICED 1-lb. vac pak pkg. OLYMPIC. Ready to serve Whole, half or quarter ib. FRESH ALBERTA Govt. Inspected Whole Roast ib. FROZEN TURKEY MATURE CANADA UTILITY GRADE FROZEN 8-16 LB. AVGE. IL Ilia BONELESS BEEF CHUCK STEAKS OR ROASTS CANADA GRADE A BEEF Ib. START THE DAY RIGHT! Bel Air Waffles BUTTERMILK FROZEN 12-oz. net wt. pkg, Empress Syrup Waffle and Pancake 44-oz. net wt. bottle 65 Household Needs! LIQUID BLEACH for SAFEWAY Libbys Fry Pan Dinner 19Vi-o2. net wt. pkg. Libbys Fry Pan Dinner 18Vi-oz. net pkg. Christies Ritz 16-oi. net wt. pkg. Clubhouse Flakes l-oi. net wf. Clubhouse Chopped 4.62-oz. net wt. jar KRAFT Mccaroni and 7Vi-oz. O net wt. pkg. CHEESE Christies Crackers 16-oz. net wt. Neet Hair Lotion 4-oz. net wt. btle. Downy Fabric 66 fl. oz. Comet Powdered 14-oz. net wh tin CORNED SIRLOIN WIENERS GROUN BLACK SWEET BURNS CRYOVAC, BONELESS Ib. BONELESS, ROAST OR STIAK Canada Grade A Beef Idea! to B.B.Q..............Ib. BURNS BULK. Ideal for Hot Dogs.....Ib. SAFEWAY ALL PURPOSE 1-lb. bag CASINO 2 cup 100 bag pkg. DAVIDS ALMOND CRUNCH 14-oz. net wt. bag CANADA FIRST GRADE LUCERNE poly bag INSTANT TOMATO JUICE FRUIT COCKTAIL for WHITE MAGIC 128-fl. oz. jug And These At Extra Savings! PAPER NAPKINS scon WHITE or RAINBOW Pkg. of iso 59 BATHROOM TISSUE Pks. PA PCD C SCOTT colors EQti F Mr I Vff ELJ or decorated, 240-1 ply..........2 roll pkg. DETERGENT IVORY LIQUID 32 ft. oz. btie. 99 RQRATEEM PLUS .1-49 EElll FLU J BLUi...............6-lb., 4-oz. net wt. pkg. PERKY 15-oz. net wt. SPECIAL tin for Hunches For Lunches at Extra Savings LUNCH IfflEAT PRIM BARBECUE, BACON, Regular 12-oz. net wt. tin rLAIVEU TUNA BYE THE SEA, LIGHT 6-oz. net wt. tin 2 for 09 GRAPE DRINK WELCHADE 48 fl. oz. .in MARGARINE MOMS, 100% VEGETABLE.............3-ib. pkg. 89 ORANGE CRYSTALS RISE N T.6., FROZEN LASAGNA GRAND wt. pkg. 1 '59 ;