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Hutchinson News Newspaper Archives Jul 27 2015, Page 5

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Hutchinson News (Newspaper) - July 27, 2015, Hutchinson, KansasThe Hutchinson news monday july 27, 2015 a5 f rom p age o be was used Merkel said. It was a very reactive vaccine. Every infant vaccinated developed a very sore Arm and Many developed a mild fever and were irritable for the first 24 hours. Anyone with an irritable 2 month old is not a Happy Parent. In a very Small percentage of cases they developed a High fever. It was not dangerous but it was scary. Parents were unhappy with the vaccine and were refusing to give it to their kids so there was a push to develop a less reactive vaccine he said. Thatus Why it was done. Protection but. The study Merkel was involved in explored the possibility that the cellular vaccine while protecting against disease might not prevent infection. Using Baboons which react to whooping cough much the Way people do the scientists vaccinated one group with a whole cell vaccine and the other with the cellular vaccine. The study found both types of vaccines generated robust antibody responses in the animals and none of the vaccinated animals developed outward signs of pertussis disease after being exposed. That did not prevent the exposed animals however from carrying the disease and spreading infection to a vaccinated animals. Even More stunning while the Baboons that received whole cell vaccine cleared the bacteria within three weeks those receiving the cellular vaccine had the bacteria in their airways for up to six weeks the study found. Trying to calculate the bacterial Burden Merkel said carrying the disease twice a Long increases the number of bacteria in the lung by Over 100 fold. Takeaways there Are a couple of things to take away from the study Merkel said. If you Are vaccinated you Are protected he said. However if exposed you can carry it without show ing symptoms and infect others As you move around the population unaware. Moreover the longer you carry the bacteria the More Likely you will encounter someone not vaccinated under vaccinated or immune compromised he said. What this suggests is if the entire population is vaccinated with cellular there will be More people infected and More transmission he said. That explains Why there Are More cases. Reno county incidentally has done Well in recent years of having children vaccinated against Pertus Sis. Statistics from the Kansas department of health and environment show 90 per cent of children entering kindergarten in the county for the 2013 14 school year the latest data available had the required pertussis vaccine. Efficacy other National studies have examined the Long term effectiveness of the cellular vaccine and found it does not provide immunity As Long As the original whole cell which other countries incidentally still used. The duration of immunity is a Complex subject Merkel said. But in general it is fair to say the duration of immunity for cellular is Shorter than for whole cell. Exactly How Long it offers Protection is not Clear but at Best its 10 years Merkel said. Several studies suggest its less than 5 years. Most adults Are no longer benefiting from a childhood vaccine Merkel said. The question is whether or not exposure to pertussis without knowing it boosts immunity. The data on that is really All Over the place. The advisory committee on immunization practices acid is a group of medical and Public health experts put together by the cd that develop recommendations on vaccinations. That panel has not recommended tap Booster vaccines for youth beyond the required kindergarten shot before school or adults. What they really have focused on the last few years is trying to get women vaccinated during preg Nancy Merkel said. There was a fatality in Kansas this year that was an infant. Newborns Are absolutely More susceptible. They re too Young to be vaccinated and their airways Are very Small. Almost All deaths weave seen in the u. S. Are newborns which of course is heartbreaking. Mothers vaccinated during pregnancy develop antibodies and pass them through the Placenta to the baby offering Protection the first few months of its life. Its the Best thing that can be done to protect new Borns he said. Make sure your kids Are fully vaccinated Merkel said. If you re an adult and never been vaccinated get vaccinated. If you re pregnant absolutely talk to your doctor and arrange to get vaccinated. Dont wait Merkel also had one very important recommendation for Reno county residents. Someone showing Typ ical signs of having a cold thatus How pertussis starts should probably get to a doctor sooner than later so they can get an Antibiotic Merkel said. If Given Early enough it will prevent the severity of the symptoms and it will prevent trans Mission. Most people wait until they have the cough and by then its too late. That is because when infected with pertussis the bacteria replicate very quickly in the to dyes Airway. The first couple of weeks of illness Are when bacteria counts Are highest and Chance for spreading the disease greatest. As the to dyes immune system starts to work on the bacteria and Clear them from the body however is when the symptoms Start to get worse including the telltale whooping cough. Even though the bacteria by then is gone continue to be sick for a Long time after that Merkel said. The scientific Community meanwhile continues to work on understanding the disease and developing the next generation of vaccines rather than going Back to the old one. The goal is to develop the next generation acello Lar thatus not reactive but also protects against infection better than whole cell Merkel said. Sadly these things take time. We think in a year or two or maybe three Well have a Good idea of whats needed. Then comes the testing phase putting things together to see if it works the Way we Hope it works. The biggest problem with developing a new vaccine is that its impossible to test the duration of immunity until we get out and use them. It takes five or 10 years for a single Experiment on duration. Thatus a significant prob Lem. Cough from Page a1

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